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INTRODUCTION. 3

1. The evolution of the organic chemistry of medicinal substances. 4

2. Modern requirements for the drug substance. 7

3. STAGES OF THE STUDY OF BIOLOGICAL drug substance. 8

4. BASIS OF THE STRATEGY OF NEW SYNTHETIC DRUGS. 10

5. RELATIONSHIP structure - biological activity. 16

6. NEW CONCEPT DEVELOPMENT 21

Medicinal substances. 21

1.7. CLASSIFICATION OF DRUGS. 23

CONCLUSION. 25

REFERENCES. 26
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